Businesses were evacuated and roads were closed Monday morning in Hagerstown, Maryland.
Authorities have asked businesses within 1,500 feet of the scene to evacuate and the road will remain closed for an extended time.
According to Maryland State Police, the crash happened at around 6:15 am on Monday.
They said on Twitter that the crash happened along the northbound side of the road near Halfway Boulevard.
The tanker was carrying a potentially explosive chemical compound.
It was only disclosed that it was carrying ammonium nitrate but there could be more compounds that got spielled.
Ammonium Nitrate is a chemical used to make fertilizers and explosives. It’s also used as a nutrient in producing antibiotics and yeast.
First responders are headed to the scene but it’s unclear if there are any injuries.
However, images released by local ABC affiliate WJLA show the overturned truck on the side of the road without any fire visible.
Police have said the road will remain closed for an ‘extended time’ and have asked people to avoid the area.
The southbound road remains closed.
Earlier this month, a tractor-trailer hauling gasoline flipped over on an Interstate 95 off-ramp in Philadelphia and caught fire, killing the driver and shutting down the major East Coast transportation artery.
This story will be updated!